Using protein engineering to understand and modulate aggregation
نویسندگان
چکیده
منابع مشابه
Using Maturity Assessments to Understand the ERP Requirements Engineering Process
Applying standard requirements engineering (RE) processes is a major trend in today’s Enterprise Resource Planning (ERP) software engineering. It emerged five years ago with the promise to provide a mechanism helping ERP project organizations deliver their business requirements timely and within budget. This paper looks in depth at a standard ERP RE process and seeks answers to four questions: ...
متن کاملReverse-engineering Distributed Applications to Understand Their Behaviour Reverse-engineering Distributed Applications to Understand Their Behaviour
Understanding the behaviour of distributed applications is a very challenging task, due to their complexity. To manage this complexity, the top-down use of suitable abstraction hierarchies is frequently proposed. Given the size of distributed applications, manually deriving such abstraction hierarchies seems not realistic. This paper discusses tools that automate the derivation of suitable abst...
متن کاملProtein-carbohydrate and protein-protein interactions: using models to better understand and predict specific molecular recognition
v CHAPTER 1 : GENERAL INTRODUCTION 1 Thesis Organization 5 References 9 CHAPTER 2: DISTINCTIONS MADE IN THE PROTEIN RECOGNITION OF CARBOHYDRATES 14 Abstract 14 Introduction 15 Discussion 19 Conclusion 24 References 26 CHAPTER 3: SPECIFIC EMPIRICAL FREE ENERGY FUNCTION FOR AUTOMATED DOCKING OF CARBOHYDRATES TO PROTEINS 34 Abstract 34 Introduction 35 Methods 37 Results and Discussion 42 Conclusio...
متن کاملUsing structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase
Uracil-DNA glycosylases (UDGs) are highly conserved proteins that can be found in a wide range of organisms, and are involved in the DNA repair and host defense systems. UDG activity is controlled by various cellular factors, including the uracil-DNA glycosylase inhibitors, which are DNA mimic proteins that prevent the DNA binding sites of UDGs from interacting with their DNA substrate. To date...
متن کاملBiophysical Insights into How Surfaces, Including Lipid Membranes, Modulate Protein Aggregation Related to Neurodegeneration
There are a vast number of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), associated with the rearrangement of specific proteins to non-native conformations that promotes aggregation and deposition within tissues and/or cellular compartments. These diseases are commonly classified as protein-misfolding or amyloid diseases...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2020
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2020.01.005